[CAS NO. 1191252-49-9] IOWH032
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PRODUCTS SPECIFICATIONS [1191252-49-9]
Store
Catalog
SLK-S7329
Brand
Selleck
CAS
1191252-49-9
DESCRIPTION [1191252-49-9]
Overview
| MDL | MFCD25977119 |
|---|---|
| Molecular Weight | 545.18 |
| Molecular Formula | C22H15Br2N3O4 |
| SMILES | O=C(C1=NC(C2=CC(Br)=C(O)C(Br)=C2)=NO1)NCC3=CC=C(OC4=CC=CC=C4)C=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8343 mL | 9.1713 mL | 18.3426 mL |
| 5 mM | 0.3669 mL | 1.8343 mL | 3.6685 mL |
| 10 mM | 0.1834 mL | 0.9171 mL | 1.8343 mL |
| 50 mM | 0.0367 mL | 0.1834 mL | 0.3669 mL |
Description
IOWH032 is a synthetic inhibitor with of 1.01 μM in CHO-CFTR cell based assays. Phase 2.
Targets
| CFTR [1] |
| 1.01 μM |
In vitro
IOWH032 shows inhibitory activity against CFTR in T84-CFTR cell based assays with IC50 of 6.87 μM.
In vivo
In a mouse closed-loop model, IOWH032 causes a statistical significant inhibition against cholera toxin (CTX) induced secretion. IOWH032 (5 mg/kg) reduces the fecal output index by ~70% in a cecetomized rat model.
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