[CAS NO. 1469337-95-8] K-Ras(G12C) inhibitor 12

Name: K-Ras(G12C) inhibitor 12
Brand: Arctom Scientific
SKU: SLK-S7331

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PRODUCTS SPECIFICATIONS [1469337-95-8]

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Catalog

SLK-S7331

Brand

Selleck

CAS

1469337-95-8

DESCRIPTION [1469337-95-8]

Overview

MDL	-
Molecular Weight	449.67
Molecular Formula	C15H17ClIN3O3
SMILES	C=CC(N1CCN(C(CNC2=CC(I)=C(Cl)C=C2O)=O)CC1)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2239 mL	11.1193 mL	22.2385 mL
5 mM	0.4448 mL	2.2239 mL	4.4477 mL
10 mM	0.2224 mL	1.1119 mL	2.2239 mL
50 mM	0.0445 mL	0.2224 mL	0.4448 mL

Description

K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic .

Targets

K-Ras(G12C) ^[1]

In vitro

K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines.

References

[1] Ostrem JM, et al. Nature. 2013, 503(7477), 548-551.