[CAS NO. 1469337-91-4] K-Ras(G12C) inhibitor 9

Name: K-Ras(G12C) inhibitor 9
Brand: Arctom Scientific
SKU: SLK-S7332

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PRODUCTS SPECIFICATIONS [1469337-91-4]

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Catalog

SLK-S7332

Brand

Selleck

CAS

1469337-91-4

DESCRIPTION [1469337-91-4]

Overview

MDL	-
Molecular Weight	513.78
Molecular Formula	C16H21ClIN3O4S
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9464 mL	9.7318 mL	19.4636 mL
5 mM	0.3893 mL	1.9464 mL	3.8927 mL
10 mM	0.1946 mL	0.9732 mL	1.9464 mL
50 mM	0.0389 mL	0.1946 mL	0.3893 mL

Description

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic .

Targets

K-Ras(G12C) ^[1]

In vitro

K-Ras(G12C) inhibitor 9 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines.

References

[1] Ostrem JM, et al. Nature. 2013, 503(7477), 548-551.