[CAS NO. 1456632-40-8] SH-4-54
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PRODUCTS SPECIFICATIONS [1456632-40-8]
Store
Catalog
SLK-S7337
Brand
Selleck
CAS
1456632-40-8
DESCRIPTION [1456632-40-8]
Overview
| MDL | MFCD28143917 |
|---|---|
| Molecular Weight | 610.59 |
| Molecular Formula | C29H27F5N2O5S |
| SMILES | O=C(O)C1=CC=C(N(CC2=CC=C(C3CCCCC3)C=C2)C(CN(C)S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)=O)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6378 mL | 8.1888 mL | 16.3776 mL |
| 5 mM | 0.3276 mL | 1.6378 mL | 3.2755 mL |
| 10 mM | 0.1638 mL | 0.8189 mL | 1.6378 mL |
| 50 mM | 0.0328 mL | 0.1638 mL | 0.3276 mL |
Description
SH-4-54 is a potent inhibitor with of 300 nM and 464 nM for STAT3 and STAT5, respectively.
In vitro
SH-4-54 shows unprecedented cytotoxicity in human glioblastoma brain cancer stem cells (BTSCs), while has no toxicity in human fetal astrocytes. In addition, SH-4-54 effectively suppresses STAT3 phosphorylation and its downstream transcriptional targets.
In vivo
In mice orthotopically xenografted with BT73, SH-4-54 (10 mg/kg i.p.) exhibits BBB permeability, potently suppresses glioma tumor growth, and inhibits pSTAT3.
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