[CAS NO. 196309-76-9] Bay 11-7085

Name: Bay 11-7085
Brand: Arctom Scientific
SKU: SLK-S7352

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PRODUCTS SPECIFICATIONS [196309-76-9]

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Catalog

SLK-S7352

Brand

Selleck

CAS

196309-76-9

DESCRIPTION [196309-76-9]

Overview

MDL	MFCD01862602
Molecular Weight	249.33
Molecular Formula	C13H15NO2S
SMILES	S(/C=C/C#N)(=O)(=O)C1=CC=C(C(C)(C)C)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.0107 mL	20.0537 mL	40.1075 mL
5 mM	0.8021 mL	4.0107 mL	8.0215 mL
10 mM	0.4011 mL	2.0054 mL	4.0107 mL
50 mM	0.0802 mL	0.4011 mL	0.8021 mL

Description

BAY 11-7085 (Bay 11-7083) is an irreversible inhibitor of TNFα-induced phosphorylation with of 10 μM.

Features

Selective IκBα phosphorylation inhibitor.

Targets

IκBα phosphorylation ^[1]

10 μM

In vitro

BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells.

In vivo

BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells.

References

[1] Pierce JW, et al. J Biol Chem. 1997, 272(34), 21096-21103.
[2] Koedel U, et al. J Infect Dis. 2000, 182(5), 1437-1445.
[3] Mabuchi S, et al. Clin Cancer Res. 2004, 10(22), 7645-7654.
[4] Hussain AR, et al. PLoS One. 2012, 7(6), e39945.

Synonyms

2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-

2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (E)-

(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile

BAY 117083

BAY 11-7085

BAY 11-70585