[CAS NO. 1095253-39-6] ARQ 621

Name: ARQ 621
Brand: Arctom Scientific
SKU: SLK-S7355

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PRODUCTS SPECIFICATIONS [1095253-39-6]

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Catalog

SLK-S7355

Brand

Selleck

CAS

1095253-39-6

DESCRIPTION [1095253-39-6]

Overview

MDL	-
Molecular Weight	552.43
Molecular Formula	C28H24Cl2FN5O2
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8102 mL	9.0509 mL	18.1018 mL
5 mM	0.3620 mL	1.8102 mL	3.6204 mL
10 mM	0.1810 mL	0.9051 mL	1.8102 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL

Description

ARQ 621 is an allosteric, and selective inhibitor. Phase 1.

Targets

Eg5 mitotic motor protein ^[1]

In vitro

ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells.

In vivo

ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs.

References

[1] Rosen L, et al. Annual Meeting of ASCO: abstract 3076