[CAS NO. 197855-65-5] Z-FA-FMK

Name: Z-FA-FMK
Brand: Arctom Scientific
SKU: SLK-S7391

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PRODUCTS SPECIFICATIONS [197855-65-5]

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Catalog

SLK-S7391

Brand

Selleck

CAS

197855-65-5

DESCRIPTION [197855-65-5]

Overview

MDL	MFCD02684535
Molecular Weight	386.42
Molecular Formula	C21 H23 F N2 O4
SMILES	O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(NC(C(CF)=O)C)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5879 mL	12.9393 mL	25.8786 mL
5 mM	0.5176 mL	2.5879 mL	5.1757 mL
10 mM	0.2588 mL	1.2939 mL	2.5879 mL
50 mM	0.0518 mL	0.2588 mL	0.5176 mL

Description

Z-FA-FMK ((1S)-Z-FA-FMK) is an irreversible inhibitor, and also inhibits effector caspases.

Targets

cysteine protease ^[1]

In vitro

Z-FA-FMK inhibits the degradation of fibrillar collagen by fibroblasts and osteoclasts. Z-FA-FMK inhibits LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Z-FA-FMK efficiently blocks T cell proliferation induced by mitogens and IL-2 in vitro.

In vivo

Z-FA-FMK significantly increases pneumococcal growth in both lungs and blood in a mouse model of intranasal pneumococcal infection. Z-FA-FMK blocks reovirus infection of Ras oncogenic tumours and host heart tissues in severe combined immunodeficiency mice.

References

[1] Rasnick D. Anal Biochem. 1985, 149(2), 461-465.
[2] van Noorden CJ, et al. Biochem Biophys Res Commun. 1991, 178(1), 178-184.
[3] Schotte P, et al. J Biol Chem. 2001, 276(24), 21153-21157.
[4] Lawrence CP, et al. J Immunol. 2006, 177(6), 3827-3836.
[5] Kim M, et al. Antivir Ther. 2010, 15(6), 897-905.