[CAS NO. 88321-09-9] Aloxistatin (E64d)

Name: Aloxistatin (E64d)
Brand: Arctom Scientific
SKU: SLK-S7393

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PRODUCTS SPECIFICATIONS [88321-09-9]

Store

Catalog

SLK-S7393

Brand

Selleck

CAS

88321-09-9

DESCRIPTION [88321-09-9]

Overview

MDL	MFCD00132883
Molecular Weight	342.43
Molecular Formula	C17H30N2O5
SMILES	C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(OCC)=O)O1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9203 mL	14.6015 mL	29.2030 mL
5 mM	0.5841 mL	2.9203 mL	5.8406 mL
10 mM	0.2920 mL	1.4602 mL	2.9203 mL
50 mM	0.0584 mL	0.2920 mL	0.5841 mL

Description

Aloxistatin (E64d) is an irreversible and membrane-permeable inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellular entry of SARS-CoV-2 pseudovirions by 92.3%.

Targets

Cysteine protease ^[1]

In vitro

Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain. Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro.

References

[1] Tamai M, et al. J Pharmacobiodyn. 1986, 9(8), 672-677.
[2] McGowan EB, et al. Biochem Biophys Res Commun. 1989, 158(2), 432-435.
[3] Murray EJ, et al. Metabolism. 1997 , 46(9), 1090-1094.
[4] Ray SK, et al. Ann N Y Acad Sci. 2001, 939, 436-449.
[5] Hook G, et al. J Alzheimers Dis. 2011, 26(2), 387-408.
[6] Dong L, et al. Nat Commun. 2022 Aug 16;13(1):4804.

Synonyms

2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, [2S-[2α,3β(R*)]]-

Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, ethyl ester, (2S,3S)-

EP 453

EST

E 64d

Loxistatin

E 64c ethyl ester

Aloxistatin

EST (pharmaceutical)

NSC 694281

Pepstatin E64d

E64d/pepstatin