[CAS NO. 117591-20-5] Calpeptin

Name: Calpeptin
Brand: Arctom Scientific
SKU: SLK-S7396

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PRODUCTS SPECIFICATIONS [117591-20-5]

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Catalog

SLK-S7396

Brand

Selleck

CAS

117591-20-5

DESCRIPTION [117591-20-5]

Overview

MDL	MFCD00155623
Molecular Weight	362.46
Molecular Formula	C20H30N2O4
SMILES	[C@H](C(N[C@@H](CCCC)C=O)=O)(NC(OCC1=CC=CC=C1)=O)CC(C)C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7589 mL	13.7946 mL	27.5893 mL
5 mM	0.5518 mL	2.7589 mL	5.5179 mL
10 mM	0.2759 mL	1.3795 mL	2.7589 mL
50 mM	0.0552 mL	0.2759 mL	0.5518 mL

Description

Calpeptin is a potent, cell-permeable inhibitor with of 52 nM, 34 nM, 138 nM, and 40 nM for Calpain I (porcine erythrocytes), Calpain II (porcine kidney), Papainb, and Calpain I (human platelets), respectively. Calpeptin attenuates and intracellular inflammatory changes in muscle cells.

Targets

Calpain II (porcine kidney) ^[1]	Calpain I (human platelets) ^[1]	Calpain I (porcine erythrocytes) ^[1]	Papainb ^[1]
34 nM(ID50)	40 nM(ID50)	52 nM(ID50)	138 nM(ID50)

In vitro

Calpeptin inhibits 20K phosphorylation in a dose-related manner in platelets stimulated by thrombin, ionomycin or collagen. In differentiating PC12 cells, Calpeptin promotes neurite elongation via inhibition of Calpain activity. In rat retinal ganglion cells, Calpeptin attenuates apoptosis, maintains normal whole-cell membrane potential, and thus provides functional neuroprotection.

In vivo

In a feline right ventricular (RV) PO (RVPO) model, calpeptin (0.6 mg/kg, i.v.) blocks the activation of calpain and caspase-3, cleavage of their substrates, and cardiomyocyte programmed cell death. In a rat focal cerebral ischemia–reperfusion injury model, Calpeptin reduces the neuronal apoptosis in hippocampal CA1 sector via inhibition of the expression of Caspase-3.

References

[1] Tsujinaka T, et al. Biochem Biophys Res Commun. 1988, 153(3), 1201-1208.
[2] Pintér M, et al. Neurosci Lett. 1994, 170(1), 91-93
[3] Das A, et al. Brain Res. 2006, 1084(1), 146-157.
[4] Mani SK, et al. Am J Physiol Heart Circ Physiol. 2008, 295(1), H314-326.
[5] Peng S, et al. Mol Biol Rep. 2011, 38(2), 905-912.

Synonyms

Carbamic acid, N-[(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Carbamic acid, [1-[[(1-formylpentyl)amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester, [S-(R*,R*)]-

Carbamic acid, [(1S)-1-[[[(1S)-1-formylpentyl]amino]carbonyl]-3-methylbutyl]-, phenylmethyl ester

Calpeptin

N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinal