[CAS NO. 522629-08-9] CGP 57380
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [522629-08-9]
Store
Catalog
SLK-S7421
Brand
Selleck
CAS
522629-08-9
DESCRIPTION [522629-08-9]
Overview
| MDL | MFCD03861062 |
|---|---|
| Molecular Weight | 244.23 |
| Molecular Formula | C11H9FN6 |
| SMILES | NC1=C2C(NN=C2NC3=CC=C(F)C=C3)=NC=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.0945 mL | 20.4725 mL | 40.9450 mL |
| 5 mM | 0.8189 mL | 4.0945 mL | 8.1890 mL |
| 10 mM | 0.4095 mL | 2.0473 mL | 4.0945 mL |
| 50 mM | 0.0819 mL | 0.4095 mL | 0.8189 mL |
Description
CGP 57380 is a potent inhibitor with of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. CGP 57380 upregulates and potentiates radiation-induced .
Targets
| MNK1 [1] (Cell-free assay) |
| 2.2 μM |
In vitro
CGP57380 inhibits phosphorylation of eIF4E in cellular assays with IC50 of about 3 μM. CGP57380 causes dephosphorylation of eIF4E, and induces a further increase in the cap-dependent reporter in 293 cells. CGP57380 results in dose-dependent decreases in Ang II-stimulated phosphorylation of eIF4E, protein synthesis, and VSMC hypertrophy. CGP57380 sensitizes wild-type cells for serum-withdrawal induced apoptosis in mouse embryo fibroblasts (MEFs). CGP57380 prevents the serial replating function of BC progenitors.
In vivo
CGP57380 (40 mg/kg/d i.p.) potently extinguishes the ability of BC CML cells to serially transplant-immunodeficient mice and function as LSCs.
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.