[CAS NO. 1188890-41-6] KN-93 Phosphate

Name: KN-93 Phosphate
Brand: Arctom Scientific
SKU: SLK-S7423

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PRODUCTS SPECIFICATIONS [1188890-41-6]

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Catalog

SLK-S7423

Brand

Selleck

CAS

1188890-41-6

DESCRIPTION [1188890-41-6]

Overview

MDL	MFCD03788201
Molecular Weight	599.03
Molecular Formula	C26 H29 Cl N2 O4 S . H3 O4 P
SMILES	P(=O)(O)(O)O.N(S(=O)(=O)C1=CC=C(OC)C=C1)(CCO)C2=C(CN(C/C=C/C3=CC=C(Cl)C=C3)C)C=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

KN-93 Phosphate is a potent and specific inhibitor of with of 0.37 μM, no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 attenuates CaMKII-induced .

Targets

CaMKII ^[1]
(Cell-free assay)

0.37 μM(Ki)

In vitro

KN-93 inhibits dopamine formation in PC12h cells by modulating the reaction rate of TH to reduce the Ca(2+)-mediated phosphorylation levels of the TH molecule. KN-93 inhibits serum-induced fibroblast cell growth with IC50 of 8 μM, and induces apoptosis after prolonged G1 arrest. KN-93 inhibits androgen receptor activity and p53-independently induces cell death in PCa cells.

In vivo

KN-93 (5 μg) ameliorates levodopa-induced dyskinesia by lowering the expression of pGluR1S845 in a rat model of Parkinson’s disease. In MRL/lpr Foxp3-GFP mice, KN-93 results in a significant induction of Treg cells in the spleen, peripheral lymph nodes and peripheral blood, and decreases skin and kidney damage.

References

[1] Sumi M, et al. Biochem Biophys Res Commun. 1991, 181(3), 968-975.
[2] Tombes RM, et al. Cell Growth Differ. 1995, 6(9), 1063-1070.
[3] Rokhlin OW, et al. Cancer Biol Ther. 2010, 9(3), 224-235.
[4] Yang X, et al. Neuropsychiatr Dis Treat. 2013, 9, 1213-1220.
[5] Koga T, et al. Autoimmunity. 2014, 15, 1-6.

Synonyms

Benzenesulfonamide, N-[2-[[[(2E)-3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxy-, phosphate (1:1)