[CAS NO. 1047953-91-2] MI-2 (MALT1 inhibitor)
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PRODUCTS SPECIFICATIONS [1047953-91-2]
Store
Catalog
SLK-S7429
Brand
Selleck
CAS
1047953-91-2
DESCRIPTION [1047953-91-2]
Overview
| MDL | MFCD19754074 |
|---|---|
| Molecular Weight | 455.72 |
| Molecular Formula | C19H17Cl3N4O3 |
| SMILES | O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1943 mL | 10.9716 mL | 21.9433 mL |
| 5 mM | 0.4389 mL | 2.1943 mL | 4.3887 mL |
| 10 mM | 0.2194 mL | 1.0972 mL | 2.1943 mL |
| 50 mM | 0.0439 mL | 0.2194 mL | 0.4389 mL |
Description
MI-2 (MALT1 inhibitor) is an irreversible inhibitor with of 5.84 μM.
Targets
| MALT1 [1] (cell-free assay) |
| 5.84 μM |
In vitro
MI-2 inhibits MALT1 functions in ABC-DLBCL cell lines with excellent cell penetration. MI-2 produces selective growth inhibition for MALT1-dependent cell lines with GI50 of 0.2, 0.5, 0.4, and 0.4 礛 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, whereas the ABC-DLBCL MALT1-independent cell lines, U2932 and HLY-1, and the two GCB-DLBCL cell lines were resistant.
In vivo
MI-2 (350 mg/kg) is nontoxic to mice. MI-2 (25 mg/kg/day i.p.) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts, whereas it has no effect on the growth of OCI-Ly1 tumors.
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