[CAS NO. 1164470-53-4] Sal003
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PRODUCTS SPECIFICATIONS [1164470-53-4]
Store
Catalog
SLK-S7437
Brand
Selleck
CAS
1164470-53-4
DESCRIPTION [1164470-53-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 463.21 |
| Molecular Formula | C18H15Cl4N3OS |
| SMILES | O=C(NC(NC(NC1=CC=C(Cl)C=C1)=S)C(Cl)(Cl)Cl)/C=C/C2=CC=CC=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1588 mL | 10.7942 mL | 21.5885 mL |
| 5 mM | 0.4318 mL | 2.1588 mL | 4.3177 mL |
| 10 mM | 0.2159 mL | 1.0794 mL | 2.1588 mL |
| 50 mM | 0.0432 mL | 0.2159 mL | 0.4318 mL |
Description
Sal003 is a potent and cell-permeable inhibitor.
Targets
| eIF-2α phosphatase [1] |
In vitro
Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB).
In vivo
Sal003 impairs spatial long-term memory formation in rats.
References
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