[CAS NO. 1133819-87-0] Azemiglitazone (MSDC-0602)
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PRODUCTS SPECIFICATIONS [1133819-87-0]
Store
Catalog
SLK-S7454
Brand
Selleck
CAS
1133819-87-0
DESCRIPTION [1133819-87-0]
Overview
| MDL | MFCD28502493 |
|---|---|
| Molecular Weight | 371.41 |
| Molecular Formula | C19H17NO5S |
| SMILES | - |
For research use only.
Storage
2 years -80 in solvent
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Targets
| MPC [1] |
In vitro
Azemiglitazone (MSDC-0602) is a modified hiazolidinediones (TZDP) with alterations in the carbon backbone that limit the ability to bind PPARγ, with the IC50 for PPARγ of 18.25 μM. Azemiglitazone (MSDC-0602) also shows the affinity for mitochondrial binding, with the IC50 of 1.38 μM. Using a Gal4-PPARγ construct containing the ligand binding domain of mouse PPARγ, MSDC-0602 only minimally activates Gal4-PPARγ in HepG2 cells even at a concentration of 50 μM.[1][2]
References
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