[CAS NO. 1515856-92-4] XEN445

Name: XEN445
Brand: Arctom Scientific
SKU: SLK-S7457

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PRODUCTS SPECIFICATIONS [1515856-92-4]

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Catalog

SLK-S7457

Brand

Selleck

CAS

1515856-92-4

MDL	MFCD28166367
Molecular Weight	366.33
Molecular Formula	C18H17F3N2O3
SMILES	O=C(C1=CC(C(F)(F)F)=CC=C1N2C[C@H](CC2)OCC3=NC=CC=C3)O

For research use only.

3 years,-20°C,powder
1 years,-80°C,in solvent

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

XEN445 is a potent and selective inhibitor with of 0.237 μM.

endothelial lipase ^[1]

0.237 μM

XEN445 shows good in vitro inhibitory potency against EL, and high selectivity over LPL and HL.

In vivo, XEN445 displays good ADME and PK properties. In mice, XEN445 (30 mg/kg, p.o.) raises plasma HDL-cholesterol concentration.