[CAS NO. 1403783-31-2] Nexturastat A
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PRODUCTS SPECIFICATIONS [1403783-31-2]
Store
Catalog
SLK-S7473
Brand
Selleck
CAS
1403783-31-2
DESCRIPTION [1403783-31-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 341.4 |
| Molecular Formula | C19 H23 N3 O3 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9291 mL | 14.6456 mL | 29.2912 mL |
| 5 mM | 0.5858 mL | 2.9291 mL | 5.8582 mL |
| 10 mM | 0.2929 mL | 1.4646 mL | 2.9291 mL |
| 50 mM | 0.0586 mL | 0.2929 mL | 0.5858 mL |
Description
Nexturastat A is a potent and selective inhibitor with of 5 nM, >190-fold selectivity over other HDACs.
Features
Urea-based HDAC6-selective inhibitor.
Targets
| HDAC6 [1] (Cell-free assay) |
| 5 nM |
In vitro
In B16 murine melanoma cells, Nexturastat A leads to a dose-dependent increase of acetyl α-tubulin levels without a concomitant elevation of histone H3 acetylation. Moreover, Nexturastat A potently inhibits the growth of B16 melanoma cells with GI50 of 14.3 μM.
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