[CAS NO. 865362-74-9] FR 180204
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PRODUCTS SPECIFICATIONS [865362-74-9]
Store
Catalog
SLK-S7524
Brand
Selleck
CAS
865362-74-9
DESCRIPTION [865362-74-9]
Overview
| MDL | MFCD14585805 |
|---|---|
| Molecular Weight | 327.34 |
| Molecular Formula | C18 H13 N7 |
| SMILES | NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0549 mL | 15.2746 mL | 30.5493 mL |
| 5 mM | 0.6110 mL | 3.0549 mL | 6.1099 mL |
| 10 mM | 0.3055 mL | 1.5275 mL | 3.0549 mL |
| 50 mM | 0.0611 mL | 0.3055 mL | 0.6110 mL |
Description
FR 180204 is an ATP-competitive, selective inhibitor with of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. It is 30-fold less potent against the related kinase p38α and failed to inhibit any kinases(MEK1, MKK4, IKKα, PKCα, Src, Syc, and PDGFα) at less than 30 μM.
Features
ERK1/ERK2-selective inhibitor
In vitro
In AP-1-transfected cells, FR180204 dose-dependently inhibits AP-1 transactivation with IC50 of 3.1 μM. FR 180204 inhibits spontaneous mesothelioma cell growth.
In vivo
In collagen-induced arthritis mice, FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss. In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves Clinical parameters.
References
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