[CAS NO. 1173022-16-6] RS-102895 Hydrochloride
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PRODUCTS SPECIFICATIONS [1173022-16-6]
Store
Catalog
SLK-S7538
Brand
Selleck
CAS
1173022-16-6
DESCRIPTION [1173022-16-6]
Overview
| MDL | MFCD08703093 |
|---|---|
| Molecular Weight | 426.86 |
| Molecular Formula | C21H22ClF3N2O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3427 mL | 11.7134 mL | 23.4269 mL |
| 5 mM | 0.4685 mL | 2.3427 mL | 4.6854 mL |
| 10 mM | 0.2343 mL | 1.1713 mL | 2.3427 mL |
| 50 mM | 0.0469 mL | 0.2343 mL | 0.4685 mL |
Description
RS-102895 hydrochloride (HCl) is a potent antagonist of with IC50 of 360 nM, and shows no effect on CCR1. RS-102895 hydrochloride also inhibits , rat brain cortex in cells with IC50s of 130 nM, 320 nM, 470 nM, respectively.
Targets
In vitro
An in vitro chemotaxis assay validates the effect of RS-102895 on leukocyte chemotaxis toward CCL2. The results suggest that increased CCL2 in SS kidneys is important in the early recruitment of leukocytes, and blockade of this recruitment by administering RS-102895 subsequently blunts the renal damage and hypertension.[2]
References
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