[CAS NO. 205678-31-5] SB273005
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PRODUCTS SPECIFICATIONS [205678-31-5]
Store
Catalog
SLK-S7540
Brand
Selleck
CAS
205678-31-5
DESCRIPTION [205678-31-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 451.44 |
| Molecular Formula | C22H24F3N3O4 |
| SMILES | CNC1=CC=CC(=N1)CCOC2=CC3=C(CC(C(=O)N(C3)CC(F)(F)F)CC(=O)O)C=C2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
SB273005 is a potent inhibitor with of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
In vitro
In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM).
References
[1] Miller WH, et al. J Med Chem. 2000, 43(1), 22-26.
[2] Badger AM, et al. Arthritis Rheum. 2001, 44(1), 128-137.
[3] Gomes N, et al. Clin Exp Metastasis. 2004, 21(6), 553-561.
[4] Rehm S, et al. Toxicol Pathol. 2007, 35(7), 958-971.
[5] Wang S, et al. Exp Ther Med. 2014, 7(6), 1677-1682.
[6] Ablain J, et al. Nat Genet. 2022 Dec;54(12):1839-1852.
[2] Badger AM, et al. Arthritis Rheum. 2001, 44(1), 128-137.
[3] Gomes N, et al. Clin Exp Metastasis. 2004, 21(6), 553-561.
[4] Rehm S, et al. Toxicol Pathol. 2007, 35(7), 958-971.
[5] Wang S, et al. Exp Ther Med. 2014, 7(6), 1677-1682.
[6] Ablain J, et al. Nat Genet. 2022 Dec;54(12):1839-1852.
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