[CAS NO. 20069-09-4] Piperlongumine

Name: Piperlongumine
Brand: Arctom Scientific
SKU: SLK-S7551

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PRODUCTS SPECIFICATIONS [20069-09-4]

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Catalog

SLK-S7551

Brand

Selleck

CAS

20069-09-4

DESCRIPTION [20069-09-4]

Overview

MDL	MFCD00075706
Molecular Weight	317.34
Molecular Formula	C17H19NO5
SMILES	O(C)C1=C(OC)C(OC)=CC(/C=C/C(=O)N2C(=O)C=CCC2)=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.1512 mL	15.7560 mL	31.5119 mL
5 mM	0.6302 mL	3.1512 mL	6.3024 mL
10 mM	0.3151 mL	1.5756 mL	3.1512 mL
50 mM	0.0630 mL	0.3151 mL	0.6302 mL

Description

Piperlongumine (PPLGM, Piplartine), a natural alkaloid from Piper longum L., increases the level of reactive oxygen species (ROS) and selectively kills cancer cells. It is a direct inhibitor with suppressive activity against gastric cancer and a novel inhibitor of ; also an inhibitor of in human breast cancer cells.

Targets

reactive oxygen species (ROS) ^[1]

TrxR1 ^[5]

CRM1 ^[6]

PI3K/Akt/mTOR ^[7]

In vitro

Piperlongumine is a known ROS inducer which could induce pancreatic cancer cell death in cell culture As a thromboxane A(2) receptor antagonist, Piperlongumine inhibits platelet aggregation. Piperlongumine also promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death.

In vivo

Piperlongumine (50 mg/kg i.p.) causes in vivo growth inhibition of tumor cells without leading to major changes in the biochemical, hematological and histopathological parameters.

References

[1] Dhillon H, et al. Toxicol Rep. 2014, 1:309-318.
[2] Iwashita M, et al. Eur J Pharmacol. 2007, 570(1-3), 38-42.
[3] Ryu J, et al. Nat Prod Res. 2014, 28(22), 2040-2043.
[4] Bezerra DP, et al. J Appl Toxicol. 2008, 28(5), 599-607.
[5] Zou P, et al. Cancer Lett. 2016, 375(1):114-26.
[6] Niu M, et al. Chem Biol Interact. 2015, 237:66-72.
[7] Shrivastava S, et al. Apoptosis. 2014, 19(7):1148-64.

Synonyms

2(1H)-Pyridinone, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-

2(1H)-Pyridone, 5,6-dihydro-1-(3,4,5-trimethoxycinnamoyl)-

2(1H)-Pyridinone, 5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-, (E)-

2(1H)-Pyridinone, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-

5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone

Piperlongumine

Piplartine

Piplartin