[CAS NO. 1056901-62-2] AT13148
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PRODUCTS SPECIFICATIONS [1056901-62-2]
Store
Catalog
SLK-S7563
Brand
Selleck
CAS
1056901-62-2
DESCRIPTION [1056901-62-2]
Overview
| MDL | MFCD25976789 |
|---|---|
| Molecular Weight | 313.78 |
| Molecular Formula | C17H16ClN3O |
| SMILES | ClC1=CC=C([C@](C2=CC=C(C3=CNN=C3)C=C2)(O)CN)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
AT13148 is an oral, ATP-competitive, multi- inhibitor with of 38 nM/402 nM/50 nM, 8 nM, 3 nM, and 6 nM/4 nM for , , , and , respectively. Phase 1.
Targets
In vitro
AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling.
In vivo
AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts.
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