[CAS NO. 837422-57-8] WH-4-023
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PRODUCTS SPECIFICATIONS [837422-57-8]
Store
Catalog
SLK-S7565
Brand
Selleck
CAS
837422-57-8
DESCRIPTION [837422-57-8]
Overview
| MDL | MFCD28138072 |
|---|---|
| Molecular Weight | 568.67 |
| Molecular Formula | C32H36N6O4 |
| SMILES | O=C(OC1=C(C)C=CC=C1C)N(C2=CC=C(OC)C=C2OC)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=NC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7585 mL | 8.7924 mL | 17.5849 mL |
| 5 mM | 0.3517 mL | 1.7585 mL | 3.5170 mL |
| 10 mM | 0.1758 mL | 0.8792 mL | 1.7585 mL |
| 50 mM | - | - | - |
Description
WH-4-023 (KIN001-112, KIN112, Dual LCK/SRC inhibitor) is a potent and orally active inhibitor with IC50s of 2 nM and 6 nM in cell-free assays, respectively. Exhibits >300-fold selectivity against p38α and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases.
In vitro
WH-4-023 shows little activity on p38 and KDR.
References
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