[CAS NO. 1129669-05-1] IM-12
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PRODUCTS SPECIFICATIONS [1129669-05-1]
Store
Catalog
SLK-S7566
Brand
Selleck
CAS
1129669-05-1
DESCRIPTION [1129669-05-1]
Overview
| MDL | MFCD20527313 |
|---|---|
| Molecular Weight | 377.41 |
| Molecular Formula | C22H20FN3O2 |
| SMILES | O=C(C(NCCC1=CC=C(F)C=C1)=C2C3=C(C)NC4=C3C=CC=C4)N(C)C2=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6496 mL | 13.2482 mL | 26.4964 mL |
| 5 mM | 0.5299 mL | 2.6496 mL | 5.2993 mL |
| 10 mM | 0.2650 mL | 1.3248 mL | 2.6496 mL |
| 50 mM | 0.0530 mL | 0.2650 mL | 0.5299 mL |
Description
IM-12 is a selective inhibitor with of 53 nM, and also enhances canonical Wnt signalling.
Targets
| GSK-3β [1] (Cell-free assay) |
| 53 nM |
In vitro
In hNPCs, IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly. Through the activation of canonical Wnt signalling pathway, IM-12 promotes the neuronal differentiation of human neural progenitor cells.
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