[CAS NO. 1418033-25-6] LMK-235
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PRODUCTS SPECIFICATIONS [1418033-25-6]
Store
Catalog
SLK-S7569
Brand
Selleck
CAS
1418033-25-6
DESCRIPTION [1418033-25-6]
Overview
| MDL | MFCD26522892 |
|---|---|
| Molecular Weight | 294.35 |
| Molecular Formula | C15H22N2O4 |
| SMILES | O=C(NOCCCCCC(NO)=O)C1=CC(C)=CC(C)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
LMK-235 is a selective inhibitor of and with of 11.9 nM and 4.2 nM, respectively.
In vitro
LMK-235 causes HDAC inhibition with IC50 of <1 μM in human cancer cell lines with different sensitivity towards cisplatin. In breast cancer cell line MDA-MB-231, tongue cancer cell line Cal27, and esophagus cell line Kyse510 cell line, LMK-235 displays a high cytotoxicity, and markedly enhances the cytotoxicity of cisplatin. In addition, LMK-235 also shows nanomolar activity against multiple malaria parasite life cycle stages.
References
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