[CAS NO. 914471-09-3] Epacadostat (INCB024360) analogue
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PRODUCTS SPECIFICATIONS [914471-09-3]
Store
Catalog
SLK-S7587
Brand
Selleck
CAS
914471-09-3
DESCRIPTION [914471-09-3]
Overview
| MDL | MFCD18633286 |
|---|---|
| Molecular Weight | 271.64 |
| Molecular Formula | C9H7ClFN5O2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6813 mL | 18.4067 mL | 36.8134 mL |
| 5 mM | 0.7363 mL | 3.6813 mL | 7.3627 mL |
| 10 mM | 0.3681 mL | 1.8407 mL | 3.6813 mL |
| 50 mM | 0.0736 mL | 0.3681 mL | 0.7363 mL |
Description
Epacadostat (INCB024360) analogue (INCB14943) is a potent, competitive inhibitor with of 67 nM.
Targets
| IDO1 [1] (Cell-free assay) |
| 67 nM |
In vitro
In HeLa cells, INCB024360 shows higher inhibitory activity on IDO1 with IC50 of 19 nM. In coculture systems of human allogeneic lymphocytes with dendritic cells or tumor cells, INCB024360, via IDO1 inhibition, reverses T-cell suppression mediated by IDO-expressing HeLa cells or DCs, and increases the proliferation and functional activity of CD4+ T cells, CD8+ T cells, and NK cells.
References
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