[CAS NO. 656820-32-5] Reversine

Name: Reversine
Brand: Arctom Scientific
SKU: SLK-S7588

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PRODUCTS SPECIFICATIONS [656820-32-5]

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Catalog

SLK-S7588

Brand

Selleck

CAS

656820-32-5

DESCRIPTION [656820-32-5]

Overview

MDL	-
Molecular Weight	393.23
Molecular Formula	C21H27N7O
SMILES	N(C1=C2C(=NC(NC3=CC=C(C=C3)N4CCOCC4)=N1)N=CN2)C5CCCCC5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5430 mL	12.7152 mL	25.4304 mL
5 mM	0.5086 mL	2.5430 mL	5.0861 mL
10 mM	0.2543 mL	1.2715 mL	2.5430 mL
50 mM	-	-	-

Description

Reversine is a potent antagonist with of 0.66 μM, and a pan- inhibitor with of 400 nM/500 nM/400 nM, respectively. Also used for stem cell dedifferentiation.

Targets

Aurora A ^[3]	Aurora B ^[3]	Aurora C ^[3]	human A3 adenosine receptor ^[2]
12 nM	13 nM	20 nM	0.66 μM(Ki)

In vitro

Reversine induces myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, which proliferates and redifferentiates into bone and fat cells. Reversine, as an A3 adenosine receptor antagonist, competitively inhibits forskolin-stimulated cAMP production in stably transfected Chinese hamster ovary (CHO) cells. Reversine inhibits the phosphorylation of a well-known Aurora target, histone H3 in HCT116 cells. Moreover, Reversine potently blocks proliferation of multiple tumor cell types, and induces cell death. In primary human tumor samples, Reversine also inhibits colony formation of leukemic cells. When treated in combination, reversine and aspirin synergistically inhibit growth of cervical cancer cells and induce cell apoptosis.

In vivo

In mice inoculated with U14 tumors, Reversine (10 mg/kg i.p.) and aspirin cause more reduced tumor weight and tumor volume when compared with the control agents.

References

[1] Chen S, et al. J Am Chem Soc. 2004, 126(2), 410-411.
[2] Perreira M, et al. J Med Chem. 2005, 48(15), 4910-4918.
[3] D'Alise AM, et al. Mol Cancer Ther. 2008, 7(5), 1140-1149.
[4] Qin HX, et al. Cytotechnology. 2013, 65(4), 643-653.

Synonyms

9H-Purine-2,6-diamine, N⁶-cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-

1H-Purine-2,6-diamine, N⁶-cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-

N⁶-Cyclohexyl-N²-[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine

Reversine