[CAS NO. 5690-03-9] Splitomicin
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PRODUCTS SPECIFICATIONS [5690-03-9]
Store
Catalog
SLK-S7593
Brand
Selleck
CAS
5690-03-9
DESCRIPTION [5690-03-9]
Overview
| MDL | MFCD08705254 |
|---|---|
| Molecular Weight | 198.22 |
| Molecular Formula | C13H10O2 |
| SMILES | O=C1OC=2C(=C3C(=CC2)C=CC=C3)CC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0449 mL | 25.2245 mL | 50.4490 mL |
| 5 mM | 1.0090 mL | 5.0449 mL | 10.0898 mL |
| 10 mM | 0.5045 mL | 2.5224 mL | 5.0449 mL |
| 50 mM | 0.1009 mL | 0.5045 mL | 1.0090 mL |
Description
Splitomicin is a selective inhibitor with of 60 μM, showing a higher activity in a cell-based assay.
Targets
| Sir2p [1] |
| 60 μM |
In vitro
Splitomicin inhibits Sir2p deacetylase activity by altering or blocking access to the acetylated histone binding pocket. Splitomicin inhibits platelet aggregation induced by thrombin, collagen, AA and U46619 via inhibition of cyclic AMP phosphodiesterase activity and subsequent inhibition of intracellular Ca(++) mobilization, TXB2 formation and ATP release.
In vivo
In a photochemical injury mouse model, splitomicin (80 mg/kg/d i.p.) enhances tissue factor activity in the arterial vessel wall and promotes carotid artery thrombus formation.
References
Synonyms
3H-Naphtho[2,1-b]pyran-3-one, 1,2-dihydro-
1-Naphthalenepropionic acid, 2-hydroxy-, δ-lactone
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
1-Naphthalenepropanoic acid, 2-hydroxy-, δ-lactone
Splitomicin
Splitomycin
1,2-Dihydro-3H-benzo[f]chromen-3-one
1,2-Dihydrobenzo[f]chromen-3-one
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