[CAS NO. 1045792-66-2] CAY10603
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PRODUCTS SPECIFICATIONS [1045792-66-2]
Store
Catalog
SLK-S7596
Brand
Selleck
CAS
1045792-66-2
DESCRIPTION [1045792-66-2]
Overview
| MDL | MFCD17010286 |
|---|---|
| Molecular Weight | 446.5 |
| Molecular Formula | C22H30N4O6 |
| SMILES | O=C(OC(C)(C)C)NC1=CC=C(C2=CC(C(NCCCCCCC(NO)=O)=O)=NO2)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2396 mL | 11.1982 mL | 22.3964 mL |
| 5 mM | 0.4479 mL | 2.2396 mL | 4.4793 mL |
| 10 mM | 0.2240 mL | 1.1198 mL | 2.2396 mL |
| 50 mM | 0.0448 mL | 0.2240 mL | 0.4479 mL |
Description
CAY10603 (BML-281) is a potent and selective inhibitor with of 2 pM, >200-fold selectivity over other HDACs.
Targets
| HDAC6 [1] (Cell-free assay) |
| 2 pM |
In vitro
CAY10603, via inhibition of HDAC6, shows potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM, which can be used as a new molecular probe in exploring HDAC biology.
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