[CAS NO. 1001600-56-1] BV-6
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PRODUCTS SPECIFICATIONS [1001600-56-1]
Store
Catalog
SLK-S7597
Brand
Selleck
CAS
1001600-56-1
DESCRIPTION [1001600-56-1]
Overview
| MDL | MFCD28168021 |
|---|---|
| Molecular Weight | 1205.57 |
| Molecular Formula | C70H96N10O8.xCF3COOH |
| SMILES | O=C(NCCCCCCNC([C@@H](NC([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@@H](NC([C@H](CCC5)N5C([C@H](C6CCCCC6)NC([C@H](C)NC)=O)=O)=O)C(C7=CC=CC=C7)C8=CC=CC=C8 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 0.8295 mL | 4.1474 mL | 8.2948 mL |
| 5 mM | 0.1659 mL | 0.8295 mL | 1.6590 mL |
| 10 mM | 0.0829 mL | 0.4147 mL | 0.8295 mL |
| 50 mM | 0.0166 mL | 0.0829 mL | 0.1659 mL |
Description
BV-6 is a SMAC mimetic, dual and inhibitor.
In vitro
BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential.
References
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