[CAS NO. 361185-42-4] RBC8
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PRODUCTS SPECIFICATIONS [361185-42-4]
Store
Catalog
SLK-S7606
Brand
Selleck
CAS
361185-42-4
DESCRIPTION [361185-42-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 424.45 |
| Molecular Formula | C25H20N4O3 |
| SMILES | N#CC(C1C2=CC(OC)=CC=C2OC)=C(N)OC3=C1C(C4=CC=C5C=CC=CC5=C4)=NN3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3560 mL | 11.7800 mL | 23.5599 mL |
| 5 mM | 0.4712 mL | 2.3560 mL | 4.7120 mL |
| 10 mM | 0.2356 mL | 1.1780 mL | 2.3560 mL |
| 50 mM | 0.0471 mL | 0.2356 mL | 0.4712 mL |
Description
RBC8 is a selective inhibitor of the and by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases Ras and RhoA.
In vitro
In living cells, RBC8 also reduces the activation of RalA by inducing chemical shift changes in RalB–GDP. In Ral-dependent lines H2122 and H358, RBC8 causes anchorage-independent growth inhibition with IC50 of 3.5 µM and 3.4 µM, respectively.
In vivo
In mice bearing H358 xenografts, RBC8 (50 mg/kg i.p.) inhibits tumor growth via specific inhibition of RalA and RalB.
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