[CAS NO. 1637739-82-2] BQU57
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PRODUCTS SPECIFICATIONS [1637739-82-2]
Store
Catalog
SLK-S7607
Brand
Selleck
CAS
1637739-82-2
DESCRIPTION [1637739-82-2]
Overview
| MDL | MFCD28902198 |
|---|---|
| Molecular Weight | 334.1 |
| Molecular Formula | C16H13F3N4O |
| SMILES | N#CC(C1C2=CC=C(C(F)(F)F)C=C2)=C(N)OC3=C1C(C)=NN3C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9931 mL | 14.9656 mL | 29.9312 mL |
| 5 mM | 0.5986 mL | 2.9931 mL | 5.9862 mL |
| 10 mM | 0.2993 mL | 1.4966 mL | 2.9931 mL |
| 50 mM | 0.0599 mL | 0.2993 mL | 0.5986 mL |
Description
BQU57, a derivative of RBC8, is a selective inhibitor relative to the GTPases Ras and RhoA.
Targets
| GTPase Ral [1] |
In vitro
In both the H2122 and H358 cell lines, BQU57 inhibits both RalA and RalB activation, and thus causes cell growth inhibition.
In vivo
In mice bearing human lung H2122 tumors, BQU57 (50 mg/kg, i.p.) significantly inhibits activation of both RalA and RalB, and causes dose-dependent tumor growth inhibition.
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