[CAS NO. 685898-44-6] PX-478 2HCl
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PRODUCTS SPECIFICATIONS [685898-44-6]
Store
Catalog
SLK-S7612
Brand
Selleck
CAS
685898-44-6
DESCRIPTION [685898-44-6]
Overview
| MDL | MFCD11840749 |
|---|---|
| Molecular Weight | 394.12 |
| Molecular Formula | C13H20Cl4N2O3 |
| SMILES | N(CCCl)(CCCl)(=O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1.Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5373 mL | 12.6865 mL | 25.3730 mL |
| 5 mM | 0.5075 mL | 2.5373 mL | 5.0746 mL |
| 10 mM | 0.2537 mL | 1.2686 mL | 2.5373 mL |
| 50 mM | 0.0507 mL | 0.2537 mL | 0.5075 mL |
Description
PX-478 2HCl is an orally active, and selective inhibitor. PX-478 2HCl induces and has anti-tumor activity. Phase 1.
Targets
| HIF-1α [1] |
In vitro
PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.
References
Synonyms
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2)
L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride
PX 478
(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride
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