[CAS NO. 254964-60-8] Tasquinimod

Name: Tasquinimod
Brand: Arctom Scientific
SKU: SLK-S7617

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PRODUCTS SPECIFICATIONS [254964-60-8]

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Catalog

SLK-S7617

Brand

Selleck

CAS

254964-60-8

DESCRIPTION [254964-60-8]

Overview

MDL	MFCD18251454
Molecular Weight	406.36
Molecular Formula	C20H17F3N2O4
SMILES	OC=1C=2C(N(C)C(=O)C1C(N(C)C3=CC=C(C(F)(F)F)C=C3)=O)=CC=CC2OC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4609 mL	12.3044 mL	24.6087 mL
5 mM	0.4922 mL	2.4609 mL	4.9217 mL
10 mM	0.2461 mL	1.2304 mL	2.4609 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL

Description

Tasquinimod (ABR-215050) is an orally active agent by allosterically inhibiting signalling. Phase 3.

Targets

HDAC4 ^[1]

In vitro

Tasquinimod inhibits tumor angiogenesis by allosteric inhibition of HDAC4/N-CoR/HDAC3 dependent deacetylation of HIF-1α. Tasquinimod also targets infiltrating myeloid cells, and modulates local tumour immunity by blocking the interaction between S100A9 and its ligands receptor of advanced glycation end products and Toll-like receptor 4.

References

[1] Isaacs JT, et al. Cancer Res.?013, 73(4), 1386-1399.
[2] Isaacs JT, et al. Prostate.?006, 66(16), 1768-1778.
[3] Raymond E, et al. Cancer Chemother Pharmacol.?014, 73(1), 1-8.
[4] Olsson A, et al. Mol Cancer. 2010 May 17;9:107.

Synonyms

3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-

1,2-Dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide

N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide

Tasquinimod

ABR 215050

4-Hydroxy-5-methoxy-N-methyl-1-methyl-2-oxo-N-(4-trifluoromethylphenyl)-1,2-dihydroquinoline-3-carboxamide