[CAS NO. 1627503-67-6] LDN-214117
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [1627503-67-6]
Store
Catalog
SLK-S7627
Brand
Selleck
CAS
1627503-67-6
DESCRIPTION [1627503-67-6]
Overview
| MDL | MFCD28168043 |
|---|---|
| Molecular Weight | 419.52 |
| Molecular Formula | C25H29N3O3 |
| SMILES | COC1=C(OC)C(OC)=CC(C2=C(C)N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3837 mL | 11.9184 mL | 23.8368 mL |
| 5 mM | 0.4767 mL | 2.3837 mL | 4.7674 mL |
| 10 mM | 0.2384 mL | 1.1918 mL | 2.3837 mL |
| 50 mM | 0.0477 mL | 0.2384 mL | 0.4767 mL |
Description
LDN-214117 is a potent and selective BMP type I receptor kinase inhibitor with of 24 nM.
Targets
| ALK2 [1] (Cell-free assay) |
| 24 nM |
In vitro
The kinase most highly inhibited by LDN-214117 is ALK2 (IC50, 24 nM), followed by TNIK, RIPK2, and ABL1. LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity. LDN-214117 exhibits relatively selective inhibition of BMP6 versus BMP2 or BMP4. In a cell-based assay, LDN-214117 exhibits a selective inhibition on BMP6 with IC50 of approximately 100 nM, and 164-fold selectivity for BMP6 versus TGF-β1.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.