[CAS NO. 717906-29-1] PF-431396
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PRODUCTS SPECIFICATIONS [717906-29-1]
Store
Catalog
SLK-S7644
Brand
Selleck
CAS
717906-29-1
DESCRIPTION [717906-29-1]
Overview
| MDL | MFCD16038300 |
|---|---|
| Molecular Weight | 506.5 |
| Molecular Formula | C22H21F3N6O3S |
| SMILES | CS(=O)(N(C)C1=CC=CC=C1CNC2=NC(NC3=CC4=C(C=C3)NC(C4)=O)=NC=C2C(F)(F)F)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9743 mL | 9.8717 mL | 19.7433 mL |
| 5 mM | 0.3949 mL | 1.9743 mL | 3.9487 mL |
| 10 mM | 0.1974 mL | 0.9872 mL | 1.9743 mL |
| 50 mM | 0.0395 mL | 0.1974 mL | 0.3949 mL |
Description
PF-431396 is a dual inhibitor with of 11 nM and 2 nM, respectively.
In vitro
In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistently inhibits the increase in protein tyrosine phosphorylation (PY) induced by the absence of added calcium and induced by W-7 in the presence of calcium.
References
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