[CAS NO. 944118-01-8] Peficitinib (ASP015K)

Name: Peficitinib (ASP015K)
Brand: Arctom Scientific
SKU: SLK-S7650

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PRODUCTS SPECIFICATIONS [944118-01-8]

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Catalog

SLK-S7650

Brand

Selleck

CAS

944118-01-8

DESCRIPTION [944118-01-8]

Overview

MDL	MFCD28502035
Molecular Weight	326.39
Molecular Formula	C18H22N4O2
SMILES	N(C1C2CC3(O)CC1CC(C2)C3)C4=C5C(=NC=C4C(N)=O)NC=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0638 mL	15.3191 mL	30.6382 mL
5 mM	0.6128 mL	3.0638 mL	6.1276 mL
10 mM	0.3064 mL	1.5319 mL	3.0638 mL
50 mM	0.0613 mL	0.3064 mL	0.6128 mL

Description

Peficitinib (ASP015K, JNJ-54781532) is an orally bioavailable inhibitor. Phase 3.

Targets

JAK ^[1]

In vitro

ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5).

References

[1] Ito M, et al. J Pharmacol Sci. 2017 Jan;133(1):25-33.

Synonyms

1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[(5-hydroxytricyclo[3.3.1.1^3,7]dec-2-yl)amino]-, stereoisomer

stereoisomer of 4-[(5-Hydroxytricyclo[3.3.1.1^3,7]dec-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

4-[(trans-5-Hydroxyadamantan-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

4-[(anti-5-Hydroxyadamantan-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

Peficitinib

ASP 015K

JNJ 54781532