[CAS NO. 4727-31-5] Kartogenin
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PRODUCTS SPECIFICATIONS [4727-31-5]
Store
Catalog
SLK-S7658
Brand
Selleck
CAS
4727-31-5
DESCRIPTION [4727-31-5]
Overview
| MDL | MFCD00560510 |
|---|---|
| Molecular Weight | 317.34 |
| Molecular Formula | C20H15NO3 |
| SMILES | O=C(O)C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1512 mL | 15.7560 mL | 31.5119 mL |
| 5 mM | 0.6302 mL | 3.1512 mL | 6.3024 mL |
| 10 mM | 0.3151 mL | 1.5756 mL | 3.1512 mL |
| 50 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL |
Description
Kartogenin (KGN) is an activator of the pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
In vitro
Kartogenin induces chondrocyte differentiation from hMSCs by enhancing the nuclear localization of CBFβ, and protects articular chondrocytes. Kartogenin promotes the type-I collagen synthesis of dermal fibroblasts via activation of the smad4/smad5 pathway without obvious cytotoxicity on fibroblasts’ viability, morphology and survival.
In vivo
Kartogenin promotes cartilage repair in collagenase VII (10 μM)– and surgery (100 μM)-induced OA models in mice. Kartogenin (100 nM) also stimulats collagen synthesis in the mouse dermis. In addition, Kartogenin stimulates mouse limb skeletal growth and synovial joint development.
References
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