[CAS NO. 459789-99-2] Obeticholic Acid
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PRODUCTS SPECIFICATIONS [459789-99-2]
Store
Catalog
SLK-S7660
Brand
Selleck
CAS
459789-99-2
DESCRIPTION [459789-99-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 420.63 |
| Molecular Formula | C26H44O4 |
| SMILES | C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCC(O)=O)C)(CC4)[H])[H])([C@H](O)[C@H](CC)[C@@]1(C[C@H](O)CC2)[H])[H])[H] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Obeticholic Acid (INT-747, 6-ECDCA, 6-Ethylchenodeoxycholic acid) is a potent and selective agonist with of 99 nM. Obeticholic Acid inhibits . Phase 3.
Targets
| FXR [1] |
| 99 nM(EC50) |
In vitro
In HuH7 cells, Obeticholic Acid acts as a potent FXR agonist with EC50 of 85 nM.
References
Synonyms
Cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3α,5β,6α,7α)-
(3α,5β,6α,7α)-6-Ethyl-3,7-dihydroxycholan-24-oic acid
6-Ethylchenodeoxycholic acid
3α,7β-Dihydroxy-6α-ethyl-5β-cholan-24-oic acid
Obeticholic acid
INT 747
6α-Ethylchenodeoxycholic acid
6-ECDCA
Ocaliva
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