[CAS NO. 215543-92-3] SU5402

Name: SU5402
Brand: Arctom Scientific
SKU: SLK-S7667

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PRODUCTS SPECIFICATIONS [215543-92-3]

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Catalog

SLK-S7667

Brand

Selleck

CAS

215543-92-3

DESCRIPTION [215543-92-3]

Overview

MDL	MFCD08235144
Molecular Weight	296.32
Molecular Formula	C17H16N2O3
SMILES	C(=C1C=2C(NC1=O)=CC=CC2)C3=C(CCC(O)=O)C(C)=CN3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3747 mL	16.8737 mL	33.7473 mL
5 mM	0.6749 mL	3.3747 mL	6.7495 mL
10 mM	0.3375 mL	1.6874 mL	3.3747 mL
50 mM	0.0675 mL	0.3375 mL	0.6749 mL

Description

SU5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.

Targets

VEGFR2 ^[1] (Cell-free assay)	FGFR1 ^[1] (Cell-free assay)	PDGFRβ ^[1] (Cell-free assay)
20 nM	30 nM	510 nM

In vitro

SU5402 inhibits VEGF-, FGF-, PDGF- dependent cell proliferation with IC50 of 0.05 μM, 2.80μM, 28.4 μM, respectively. In HUVECs, SU5416 selectively inhibits VEGF-driven mitogenesis in a dose-dependent manner with IC50 of 0.04 μM. In nasopharyngeal epithelial cells, SU5402 attenuates LMP1-mediated aerobic glycolysis, cellular transformation, cell migration, and invasion. In mouse C3H10T1/2 cells, SU 5402 diminishes the effect of FGF23 on cell differentiation.

In vivo

In mice, SU5416 (25 mg/kg, i.p.) inhibits subcutaneous growth of a panel of tumor cell lines by inhibiting the angiogenic process associated with tumor growth.

References

[1] Sun L, et al. J Med Chem. 1999, 42(25), 5120-5130.
[2] Fong TA, et al. Cancer Res. 1999, 59(1), 99-106.
[3] Lo AK, et al. J Pathol. 2015. doi: 10.1002/path.4575.
[4] Li Y, et al. Calcif Tissue Int. 2013, 93(6), 556-5 64.

Synonyms

1H-Pyrrole-3-propanoic acid, 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-

2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

SU 5402

3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone