[CAS NO. 919973-83-4] OF-1

Name: OF-1
Brand: Arctom Scientific
SKU: SLK-S7681

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PRODUCTS SPECIFICATIONS [919973-83-4]

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Catalog

SLK-S7681

Brand

Selleck

CAS

919973-83-4

DESCRIPTION [919973-83-4]

Overview

MDL	MFCD26964046
Molecular Weight	440.31
Molecular Formula	C17H18BrN3O4S
SMILES	O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2711 mL	11.3556 mL	22.7113 mL
5 mM	0.4542 mL	2.2711 mL	4.5423 mL
10 mM	0.2271 mL	1.1356 mL	2.2711 mL
50 mM	0.0454 mL	0.2271 mL	0.4542 mL

Description

OF-1 is a potent inhibitor of and bromodomain with of 100 nM and 500 nM, respectively.

Targets

BRPF1B ^[1]	BRPF2 ^[1]
100 nM(Kd)	500 nM(Kd)

In vitro

As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity.

References

[1] Structural Genomics Consortium (SGC).