[CAS NO. 946518-60-1] LY2409881
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PRODUCTS SPECIFICATIONS [946518-60-1]
Store
Catalog
SLK-S7697
Brand
Selleck
CAS
946518-60-1
DESCRIPTION [946518-60-1]
Overview
| MDL | MFCD28900676 |
|---|---|
| Molecular Weight | 594.43 |
| Molecular Formula | C24H32Cl4N6OS |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6823 mL | 8.4114 mL | 16.8228 mL |
| 5 mM | 0.3365 mL | 1.6823 mL | 3.3646 mL |
| 10 mM | 0.1682 mL | 0.8411 mL | 1.6823 mL |
| 50 mM | - | - | - |
Description
LY2409881 is a potent and selective inhibitor with of 30 nM, >10-fold selectivity over IKK1 and other common kinases.
Targets
| IKK2 [1] |
| 30 nM |
In vitro
LY2409881 inhibits constitutively activated NF-ƘB, and causes concentration- and time-dependent growth inhibition and apoptosis in diffuse large B-cell lymphoma (DLBCL) cells. In the ovarian cancer cell line SKOV3, LY2409881 demonstrates moderate cytotoxicity. LY2409881 is synergistic with doxorubicin and cyclophosphamide in SUDHL2 cell in inhibiting the cell growth, but not in LY1 cell. In both SUDHL2 and LY1 cells, LY2409881 is synergistic with the histone deacetylase (HDAC) inhibitor romidepsin in inhibiting the cell growth.
In vivo
In SCID-beige xenograft mouse model, LY2409881 (50, 100, and 200 mg/kg, i.p.) significantly inhibits the tumor growth.
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