[CAS NO. 1633044-56-0] FIIN-2

Name: FIIN-2
Brand: Arctom Scientific
SKU: SLK-S7714

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PRODUCTS SPECIFICATIONS [1633044-56-0]

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Catalog

SLK-S7714

Brand

Selleck

CAS

1633044-56-0

DESCRIPTION [1633044-56-0]

Overview

MDL	-
Molecular Weight	634.73
Molecular Formula	C35H38N8O4
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.5755 mL	7.8774 mL	15.7547 mL
5 mM	0.3151 mL	1.5755 mL	3.1509 mL
10 mM	0.1575 mL	0.7877 mL	1.5755 mL
50 mM	0.0315 mL	0.1575 mL	0.3151 mL

Description

FIIN-2 is an irreversible, pan- inhibitor with of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively.

Targets

FGFR1 ^[1] (Cell-free assay)	FGFR2 ^[1] (Cell-free assay)	FGFR3 ^[1] (Cell-free assay)	FGFR4 ^[1] (Cell-free assay)
3.09 nM	4.3 nM	27 nM	45.3 nM

In vitro

In FGFR1-4 Ba/F3 cells, FIIN-2 inhibits cell proliferation with EC50 in the single- to double-digit nanomolar range. FIIN-2 also shows excellent antiproliferative activity in a variety of backgrounds, including cell lines that have gatekeeper mutations in FGFR1 and that are dependent on FGFR4.

In vivo

In a zebrafish developmental model, FIIN-2 causes mild or severe phenotypes to the tail morphogenesis by inhibiting FGFR.

References

[1] Tan L, et al. Proc Natl Acad Sci U S A. 2014, 111(45), E4869-4877.