[CAS NO. 896705-16-1] BMH-21
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PRODUCTS SPECIFICATIONS [896705-16-1]
Store
Catalog
SLK-S7718
Brand
Selleck
CAS
896705-16-1
DESCRIPTION [896705-16-1]
Overview
| MDL | MFCD27225377 |
|---|---|
| Molecular Weight | 360.41 |
| Molecular Formula | C21H20N4O2 |
| SMILES | O=C1N2C(C(C(NCCN(C)C)=O)=CC=C2)=NC3=CC4=CC=CC=C4C=C31 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7746 mL | 13.8731 mL | 27.7462 mL |
| 5 mM | 0.5549 mL | 2.7746 mL | 5.5492 mL |
| 10 mM | 0.2775 mL | 1.3873 mL | 2.7746 mL |
| 50 mM | - | - | - |
Description
BMH-21 is a DNA intercalator, which binds ribosomal DNA and inhibits transcription.
Targets
| RNA polymerase I [1] |
In vitro
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.
References
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