[CAS NO. 1440209-96-0] BRD73954
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PRODUCTS SPECIFICATIONS [1440209-96-0]
Store
Catalog
SLK-S7726
Brand
Selleck
CAS
1440209-96-0
DESCRIPTION [1440209-96-0]
Overview
| MDL | MFCD26383435 |
|---|---|
| Molecular Weight | 284.31 |
| Molecular Formula | C16H16N2O3 |
| SMILES | O=C(NO)C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5173 mL | 17.5864 mL | 35.1729 mL |
| 5 mM | 0.7035 mL | 3.5173 mL | 7.0346 mL |
| 10 mM | 0.3517 mL | 1.7586 mL | 3.5173 mL |
| 50 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL |
Description
BRD73954 is a potent and selective inhibitor with of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
In vitro
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.
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