[CAS NO. 478336-92-4] ISO-1
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PRODUCTS SPECIFICATIONS [478336-92-4]
Store
Catalog
SLK-S7732
Brand
Selleck
CAS
478336-92-4
DESCRIPTION [478336-92-4]
Overview
| MDL | MFCD22376813 |
|---|---|
| Molecular Weight | 235.24 |
| Molecular Formula | C12H13NO4 |
| SMILES | O=C(OC)CC1CC(C2=CC=C(O)C=C2)=NO1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2510 mL | 21.2549 mL | 42.5098 mL |
| 5 mM | 0.8502 mL | 4.2510 mL | 8.5020 mL |
| 10 mM | 0.4251 mL | 2.1255 mL | 4.2510 mL |
| 50 mM | 0.0850 mL | 0.4251 mL | 0.8502 mL |
Description
ISO-1 (MIF Antagonist) is an inhibitor of with an IC50 of ~7 μM.
Targets
| MIF [1] |
| 7 μM |
In vitro
ISO-1 significantly inhibits the cytokine activity in vitro. It inhibits tumor necrosis factor release from macrophages isolated from LPStreated wild type mice but has no effect on cytokine release from MIF-deficient macrophages.
References
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