[CAS NO. 783348-36-7] MLN120B
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PRODUCTS SPECIFICATIONS [783348-36-7]
Store
Catalog
SLK-S7736
Brand
Selleck
CAS
783348-36-7
DESCRIPTION [783348-36-7]
Overview
| MDL | MFCD17392835 |
|---|---|
| Molecular Weight | 366.80 |
| Molecular Formula | C19H15ClN4O2 |
| SMILES | O=C(NC1=C(OC)C(Cl)=CC2=C1NC3=C2C=CN=C3)C4=C(C)N=CC=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7263 mL | 13.6314 mL | 27.2628 mL |
| 5 mM | 0.5453 mL | 2.7263 mL | 5.4526 mL |
| 10 mM | 0.2726 mL | 1.3631 mL | 2.7263 mL |
| 50 mM | 0.0545 mL | 0.2726 mL | 0.5453 mL |
Description
MLN120B (ML120B) is a potent, selective, reversible, and ATP-competitive inhibitor of with an IC50 of 45 nM for recombinant IKKβ. MLN120B does not inhibit other IKK isoforms at IC50 below 50 μM.
Targets
| recombinant IKKβ [1] |
| 45 nM |
In vitro
MLN120B, a anti-inflammatory compound, is a NF-kB pathway blocker of inhibiting IKK2, and shows an inhibitory effect on LPS induced NF-kB activation. The IC50 value of MLN120B is 1.4, 14.8 or 27.3 μM for NF-kB2-luc2, IL8-luc2 or TNF-AIP3-luc2 reporter transfected cells, respectively, indicating that IKK2 inhibition affects the transcriptional activity of the NF-kB2 promoter most effective.[1][2]
References
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