[CAS NO. 193551-21-2] SB239063

Name: SB239063
Brand: Arctom Scientific
SKU: SLK-S7741

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PRODUCTS SPECIFICATIONS [193551-21-2]

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Catalog

SLK-S7741

Brand

Selleck

CAS

193551-21-2

DESCRIPTION [193551-21-2]

Overview

MDL	MFCD03792786
Molecular Weight	368.4
Molecular Formula	C20H21FN4O2
SMILES	O(C)C=1N=C(C2=C(N=CN2[C@]3(CC[C@H](O)CC3)[H])C4=CC=C(F)C=C4)C=CN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7144 mL	13.5722 mL	27.1444 mL
5 mM	0.5429 mL	2.7144 mL	5.4289 mL
10 mM	0.2714 mL	1.3572 mL	2.7144 mL
50 mM	0.0543 mL	0.2714 mL	0.5429 mL

Description

SB239063 is a potent and selective inhibitor with of 44 nM, showing no activity against the γ- and δ-kinase isoforms.

Targets

p38α ^[1] (Cell-free assay)	p38β ^[1] (Cell-free assay)
44 nM	44 nM

In vitro

SB 239063 potently inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes with IC50 of 120 and 350 nM, respectively. In oxygen-glucose-deprived hippocampal slice cultures, SB239063 strikingly reduces the levels of the pro-inflammatory cytokine IL-1beta, causes cell death after oxygen-glucose deprivation and significantly diminishes microglia activation. In human corneal endothelial cell, SB 239063 inhibits TGF-β(2) and FGF-2-induced cell migration.

In vivo

In both guinea pigs and mice, SB 239063 (10 mg/kg, p.o.) reduces antigen-induced airway eosinophilia. In air- and ozone-exposed C57/BL6 and MKP-1(-/-) mice, SB239063 inhibits bronchial contraction.

References

[1] Underwood DC, et al. J Pharmacol Exp Ther. 2000, 293(1), 281-288.
[2] Strassburger M, et al. Eur J Pharmacol. 2008, 592(1-3), 55-61.
[3] Li F, et al. Eur Respir J. 2011, 37(4), 933-942.
[4] Joko T, et al. Exp Eye Res. 2013, 108, 23-32.

Synonyms

Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

SB 239063

BRD-K 98143437