[CAS NO. 789-61-7] 6-Thio-dG
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PRODUCTS SPECIFICATIONS [789-61-7]
Store
Catalog
SLK-S7757
Brand
Selleck
CAS
789-61-7
DESCRIPTION [789-61-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 283.31 |
| Molecular Formula | C10H13N5O3S |
| SMILES | S=C1C2=C(N(C=N2)[C@@]3(O[C@H](CO)[C@@H](O)C3)[H])NC(N)=N1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5297 mL | 17.6485 mL | 35.2970 mL |
| 5 mM | 0.7059 mL | 3.5297 mL | 7.0594 mL |
| 10 mM | 0.3530 mL | 1.7649 mL | 3.5297 mL |
| 50 mM | 0.0706 mL | 0.3530 mL | 0.7059 mL |
Description
6-thio-dG (β-TGdR) is a nucleoside analog and telomerase substrate.
In vitro
6-Thio-dG induces telomere dysfunction and results in progressive telomere shortening in telomerase-positive human cancer cells and hTERT-expressing human fibroblasts. In tested cancer cells, 6-thio-dG inhibits cell viability with IC50 values between 0.7 and 2.9 μM.
In vivo
In mice bearing A549 lung cancer xenografts, 6-Thio-dG (2 mg/kg, i.p.) decreases the tumorigenicity of A549 Cells by inducing telomere dysfunction.
Synonyms
Guanosine, 2′-deoxy-6-thio-
9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-
2′-Deoxy-6-thioguanosine
Thioguanine deoxyriboside
2′-Deoxythioguanosine
2′-Desoxy-6-thioguanosine
NSC 71261
β-Thioguanine deoxyriboside
2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine
TGdR
β-TGdR
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