[CAS NO. 1051375-10-0] Cabotegravir (GSK1265744)

Name: Cabotegravir (GSK1265744)
Brand: Arctom Scientific
SKU: SLK-S7766

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [1051375-10-0]

Store

Catalog

SLK-S7766

Brand

Selleck

CAS

1051375-10-0

DESCRIPTION [1051375-10-0]

Overview

MDL	MFCD25976748
Molecular Weight	405.35
Molecular Formula	C19H17F2N3O5
SMILES	O=C1C=2N(C[C@@]3(N1[C@@H](C)CO3)[H])C=C(C(NCC4=C(F)C=C(F)C=C4)=O)C(=O)C2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4670 mL	12.3350 mL	24.6700 mL
5 mM	0.4934 mL	2.4670 mL	4.9340 mL
10 mM	0.2467 mL	1.2335 mL	2.4670 mL
50 mM	0.0493 mL	0.2467 mL	0.4934 mL

Description

Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with of 3.0 nM. Phase 2.

Targets

HIV integrase ^[1]

In vitro

GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432, respectively. GSK1265744 produces cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μM in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, respectively.

In vivo

GSK1265744 (50 mg/kg) treatment protects rhesus macaques against three high-dose SHIV challenges.

References

[1] Yoshinaga T, et al. Antimicrob Agents Chemother. 2015, 59(1), 397-406.
[2] Andrews CD, et al. Sci Transl Med. 2015, 7(270), 270-274.

Synonyms

Oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-, (3S,11aR)-

(3S,11aR)-N-[(2,4-Difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide

Cabotegravir

GSK 1265744A

GSK 744

(3s,11Ar)-n-(2,4-difluorobenzyl)-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydrooxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide