[CAS NO. 212844-53-6] Purvalanol A

Name: Purvalanol A
Brand: Arctom Scientific
SKU: SLK-S7793

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PRODUCTS SPECIFICATIONS [212844-53-6]

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Catalog

SLK-S7793

Brand

Selleck

CAS

212844-53-6

DESCRIPTION [212844-53-6]

Overview

MDL	MFCD02179211
Molecular Weight	388.89
Molecular Formula	C19H25ClN6O
SMILES	N(C1=C2C(N(C(C)C)C=N2)=NC(N[C@H](C(C)C)CO)=N1)C3=CC(Cl)=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5714 mL	12.8571 mL	25.7142 mL
5 mM	0.5143 mL	2.5714 mL	5.1428 mL
10 mM	0.2571 mL	1.2857 mL	2.5714 mL
50 mM	0.0514 mL	0.2571 mL	0.5143 mL

Description

Purvalanol A is a potent, and cell-permeable inhibitor with of 4 nM, 70 nM, 35 nM, and 850 nM for cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, and cdk4-cyclin D1, respectively. Purvalanol A induces endoplasmic reticulum stress-mediated and .

Targets

Cdc2/CyclinB ^[1]	CDK2/CyclinE ^[1]	CDK2/CyclinA ^[1]	CDK4/CyclinD1 ^[1]
4 nM	35 nM	70 nM	850 nM

In vitro

Purvalanol A decreases cell viability in dose-dependent manner in MCF-7 and MDA-MB-231 cell lines. Purvalanol A induces cell viability loss by 50 % in MCF-7 cells but MDA-MB-231 cells sre less sensitive to Purvalanol A (32 % decreases in cell viability). Purvalanol A induces mitochondria-mediated apoptosis in MCF-7 and MDA-MB-231 cells. Purvalanol A effectively prevents c-Src-mediated transformation by inhibiting both cell cycle progression and c-Src signaling, and effectively suppresses the anchorage independent growth of some human cancer cells in which c-Src is up-regulated. Purvalanol A has a stronger inhibitory effect on the anchorage-independent growth of HT29 and SW480 human colon cancer cells.

References

[1] Gray NS, et al. Science. 1998, 281(5376), 533-538.
[2] Obakan P, et al. Mol Biol Rep. 2014, 41(1), 145-154.
[3] Hikita T, et al. Genes Cells. 2010, 15(10), 1051-1062.

Synonyms

1-Butanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-, (2R)-

(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purvalanol A

NG 60

(R)-Purvalanol A

(2R)-2-[[6-(3-Chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol

(2R)-2-[[6-(3-Chloroanilino)-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol